Journal: Annales d'endocrinologie
Article Title: Mucinous carcinoma of the thyroid: A case report and review of the literature.
PMID/MRN: 27659268
Publication Date: 2016-Sep-19
Abstract:
We report the case of a primary mucinous carcinoma of the thyroid in a man of 74 who had a 4-cm nodule in the right lobe of the thyroid, with a solido-cystic appearance on ultrasound associated with lymph node metastases. On scintigraphy, the nodule was hot and not extinctive. The patient underwent total thyroidectomy with a ipsilateral right lymph node dissection. The immunohistochemical study showed the negativity of CKÊ7 and CKÊ20 and the positivity of thyroglobulin and TTFÊ1. Postoperatively the rate of blood thyroglobulin 3Êmonths after surgery had collapsed to 0.17ng/ml. The evolution was marked by the appearance of pulmonary metastasis and the patient died 4Êmonths after surgery. Histological study showed the presence of almas of neoplastic cells surrounded by large deposits of extracellular mucin. Primitive mucinous carcinoma of the thyroid is a rare tumor which differential diagnosis is established on the positive immunohistochemistry of thyroglobulin and TTF1 but negative for other markers.
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