Journal: Chemistry & biodiversity
Article Title: Pyranochromones from Dictyoloma vandellianum A. Juss and Their Cytotoxic Evaluation.
PMID/MRN: 27797447
Publication Date: 2016-Oct-31
Abstract:
One new chromone 3,3-dimethylallylspatheliachromene methyl ether 1, as well as five known chromones, 6-(3-methylbut-2-enyl) allopteroxylin methyl ether 2, 6-(3-methylbut-2-enyl) allopteroxylin 3, 3,3-dimethylallylspatheliachromene 4, 5-O-methylcneorumchromone K 5 and spatheliabischromen 6, two alkaloids, 8-methoxy-N-methylflindersine 7 and 8-methoxyflindersine 8, and two limonoids, limonin diosphenol 9 and rutaevin 10, were isolated from Dictyoloma vandellianum A. Juss (Rutaceae). Cytotoxic activities towards tumor cell lines B16-F10, HepG2, K562 and HL60 and non-tumor cells PBMC were evaluated for compounds 1-6. Compound 1 was the most active showing IC 50 values ranging from 6.26 to 14.82 ?g/mL in B16-F10 and K562 cell lines, respectively, and presented IC 50 value of 11.65 ?g/mL in PBMC cell line. This article is protected by copyright. All rights reserved.
This article is protected by copyright. All rights reserved.